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In molecular biology, adenylosuccinate synthase (or adenylosuccinate synthetase) (EC 6.3.4.4) is an enzyme that plays an important role in purine biosynthesis, by catalysing the guanosine triphosphate (GTP)-dependent conversion of inosine monophosphate (IMP) and aspartic acid to guanosine diphosphate (GDP), phosphate and N(6)-(1,2-dicarboxyethyl)-AMP. Adenylosuccinate synthetase has been characterised from various sources ranging from Escherichia coli (gene purA) to vertebrate tissues. In vertebrates, two isozymes are present: one involved in purine biosynthesis and the other in the purine nucleotide cycle.

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  • Adenylosuccinate synthase (en)
  • Adenylosuccinat-Synthase (de)
  • Adénylosuccinate synthase (fr)
  • アデニロコハク酸シンターゼ (ja)
  • ADSS (uk)
rdfs:comment
  • In molecular biology, adenylosuccinate synthase (or adenylosuccinate synthetase) (EC 6.3.4.4) is an enzyme that plays an important role in purine biosynthesis, by catalysing the guanosine triphosphate (GTP)-dependent conversion of inosine monophosphate (IMP) and aspartic acid to guanosine diphosphate (GDP), phosphate and N(6)-(1,2-dicarboxyethyl)-AMP. Adenylosuccinate synthetase has been characterised from various sources ranging from Escherichia coli (gene purA) to vertebrate tissues. In vertebrates, two isozymes are present: one involved in purine biosynthesis and the other in the purine nucleotide cycle. (en)
  • Die Adenylosuccinat-Synthase (nach IUBMB auch: IMP-Aspartat-Ligase) ist das Enzym, das die Verknüpfung von IMP und Aspartat zu Adenylosuccinat katalysiert. Diese Reaktion ist Teil der De-novo-Synthese von AMP (Stoffwechsel der Purine) in allen Lebewesen. Im Menschen, wie in allen Wirbeltieren, gibt es zwei in den Muskeln und der Leber lokalisierte Isoformen, die von den Genen ADSS und ADSSL, welche sich auf den Chromosomen 1 und 14 befinden, codiert werden. (de)
  • L'adénylosuccinate synthase, ou adénylosuccinate synthétase, est une ligase qui catalyse la réaction : IMP + L-aspartate + GTP adénylosuccinate + GDP + Pi. Cette enzyme requiert l'hydrolyse concomitante d'une molécule de GTP. Le fait d'utiliser l'énergie du GTP et non de l'ATP a pour effet de rendre la réaction indépendante de son produit. Elle est présente chez tous les êtres vivants, où elle participe à la synthèse de novo de l'AMP (cycle des purines). Il en existe deux isozymes chez l'homme, dans le muscle et dans le foie, codées respectivement par les gènes ADSS et ADSSL. (fr)
  • アデニロコハク酸シンターゼ(adenylosuccinate synthase, ADSS)またはIMP-アスパラギン酸リガーゼ(IMP-aspartate ligase)はプリン代謝のうちアデニル酸の合成に関わる酵素で、以下の化学反応を触媒する。 GTP + IMP + L-アスパラギン酸 GDP + リン酸 + (ja)
  • ADSS (англ. Adenylosuccinate synthase) – білок, який кодується однойменним геном, розташованим у людей на 1-й хромосомі. Довжина поліпептидного ланцюга білка становить 456 амінокислот, а молекулярна маса — 50 097. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин (uk)
foaf:name
  • Adenylosuccinate synthase (en)
name
  • Adenylosuccinate synthase (en)
  • Adenylsucc_synt (en)
  • adenylosuccinate synthase (en)
  • adenylosuccinate synthase like 1 (en)
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  • http://commons.wikimedia.org/wiki/Special:FilePath/2v40.jpg
  • http://commons.wikimedia.org/wiki/Special:FilePath/PDB_1dj3_EBI.jpg
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OMIM
PROSITE
  • PDOC00444 (en)
SCOP
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  • structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana (en)
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