About: Apoptosis-inducing factor

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Apoptosis inducing factor is involved in initiating a caspase-independent pathway of apoptosis (positive intrinsic regulator of apoptosis) by causing DNA fragmentation and chromatin condensation. Apoptosis inducing factor is a flavoprotein. It also acts as an NADH oxidase. Another AIF function is to regulate the permeability of the mitochondrial membrane upon apoptosis. Normally it is found behind the outer membrane of the mitochondrion and is therefore secluded from the nucleus. However, when the mitochondrion is damaged, it moves to the cytosol and to the nucleus. Inactivation of AIF leads to resistance of embryonic stem cells to death following the withdrawal of growth factors indicating that it is involved in apoptosis.

Attributes	Values
rdf:type	Thing Biomolecule Biomolecule Protein yago:Abstraction100002137 yago:Chemical114806838 yago:Compound114818238 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 protein yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 yago:WikicatProteins umbel-rc:ProteinMolecule
rdfs:label	Apoptosis-inducing factor (en) Czynnik indukujący apoptozę (pl) 凋亡诱导因子 (zh)
rdfs:comment	Apoptosis inducing factor is involved in initiating a caspase-independent pathway of apoptosis (positive intrinsic regulator of apoptosis) by causing DNA fragmentation and chromatin condensation. Apoptosis inducing factor is a flavoprotein. It also acts as an NADH oxidase. Another AIF function is to regulate the permeability of the mitochondrial membrane upon apoptosis. Normally it is found behind the outer membrane of the mitochondrion and is therefore secluded from the nucleus. However, when the mitochondrion is damaged, it moves to the cytosol and to the nucleus. Inactivation of AIF leads to resistance of embryonic stem cells to death following the withdrawal of growth factors indicating that it is involved in apoptosis. (en) Czynnik indukujący apoptozę (ang. Apoptosis Inducing Factor, AIF) – niedawno odkryte białko uwalniane z przestrzeni międzybłonowej mitochondriów do cytoplazmy komórki podczas apoptozy. (pl) 凋亡诱导因子（英語：Apoptosis-inducing factor，简称为AIF）是一类进化保守的黄素蛋白。凋亡诱导因子涉及到非胱天蛋白酶依赖型细胞凋亡途径的引发，可以使得细胞的染色体凝聚及DNA的片段化。同时它又扮演还原型烟酰胺腺嘌呤二核苷酸氧化酶的角色。凋亡诱导因子的另一个功能是在细胞凋亡时调节线粒体膜的通透性。它通常位于线粒体外膜从而与细胞核隔绝开来。然而，当线粒体受损时，凋亡诱导因子就会移动到胞质溶胶与细胞核中。 (zh)
foaf:name	apoptosis-inducing factor, mitochondrion-associated, 1 (en)
name	AIFM1
foaf:depiction
dcterms:subject	Programmed cell death Cell signaling Apoptosis
Wikipage page ID	7330572 (xsd:integer)
Wikipage revision ID	1092304746 (xsd:integer)
Link from a Wikipage to another Wikipage	Electron transport chain Parthanatos DNA fragmentation Intermembrane space Programmed cell death Colorectal cancer Apoptosis Pancreatic cancer Prostate cancer Cell signaling Flavin adenine dinucleotide Epithelial-mesenchymal transition Redox AIFM3 AIFM1 AIFM2 Apoptosis X chromosome Mitogen-activated protein kinase C-terminus HLA-B associated transcript 3 Caspase Chromatin condensation Reactive oxygen species Exon XIAP Flavoprotein N-terminus NADH Target peptide Mitochondrial membrane JNK
sameAs	Apoptosis-inducing factor Apoptosis-inducing factor Apoptosis-inducing factor Apoptosis-inducing factor Apoptosis-inducing factor Apoptosis-inducing factor Apoptosis-inducing factor
dbp:wikiPageUsesTemplate	dbt:Cell_signaling dbt:MeshName dbt:Reflist dbt:Short_description dbt:Flavoproteins dbt:Protein dbt:Apoptosis_signaling_pathway
thumbnail	wiki-commons:Special:FilePath/apoptosis_inducing_factor.png?width=300
OMIM	300169 (xsd:integer)
AltSymbols	PDCD8 (en)
caption	Crystallographic structure of the human apoptosis inducing factor . (en)
symbol	AIFM1
UniProt	O95831 (en)
has abstract	Apoptosis inducing factor is involved in initiating a caspase-independent pathway of apoptosis (positive intrinsic regulator of apoptosis) by causing DNA fragmentation and chromatin condensation. Apoptosis inducing factor is a flavoprotein. It also acts as an NADH oxidase. Another AIF function is to regulate the permeability of the mitochondrial membrane upon apoptosis. Normally it is found behind the outer membrane of the mitochondrion and is therefore secluded from the nucleus. However, when the mitochondrion is damaged, it moves to the cytosol and to the nucleus. Inactivation of AIF leads to resistance of embryonic stem cells to death following the withdrawal of growth factors indicating that it is involved in apoptosis. (en) Czynnik indukujący apoptozę (ang. Apoptosis Inducing Factor, AIF) – niedawno odkryte białko uwalniane z przestrzeni międzybłonowej mitochondriów do cytoplazmy komórki podczas apoptozy. (pl) 凋亡诱导因子（英語：Apoptosis-inducing factor，简称为AIF）是一类进化保守的黄素蛋白。凋亡诱导因子涉及到非胱天蛋白酶依赖型细胞凋亡途径的引发，可以使得细胞的染色体凝聚及DNA的片段化。同时它又扮演还原型烟酰胺腺嘌呤二核苷酸氧化酶的角色。凋亡诱导因子的另一个功能是在细胞凋亡时调节线粒体膜的通透性。它通常位于线粒体外膜从而与细胞核隔绝开来。然而，当线粒体受损时，凋亡诱导因子就会移动到胞质溶胶与细胞核中。 (zh)
Arm	q (en)
band	25 (xsd:integer)
Chromosome	X (en)
EntrezGene	9131 (xsd:integer)
HGNCid	8768 (xsd:integer)
LocusSupplementaryData	-q26 (en)
RefSeq	NM_004208 (en)
locus supplementary data	-q26
gold:hypernym	Apoptosis

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