Robert "Bob" O'Keeffe (16 August 1880 – 1949) was an Irish hurler who played for the Laois senior team. O'Keeffe was a regular member of the starting fifteen during the 1914 and 1915 championship campaigns. During that time he won one All-Ireland medal and back-to-back Leinster medals. At club level O'Keeffe had a lengthy career, playing with Mooncoin in Kilkenny, St Peter's in Meath and Borris-in-Ossory in Laois.