Carlos Castillo-Chavez (born 1952) is a Mexican-American mathematician who was Regents Professor and Joaquín Bustoz Jr. Professor of Mathematical Biology at Arizona State University. Castillo-Chavez was founder and the Executive Director of the Mathematical and Theoretical Biology Institute (MTBI) and the Institute for Strengthening the Understanding of Mathematics and Science. For 2019, Castillo-Chavez was Provost Visiting Professor in the Applied Mathematics Division and Data Science Initiative at Brown University. Castillo-Chavez retired from Arizona State University at the end of spring 2020.