The Chamberlain Bridge, is a historic bridge connecting the towns of Chamberlain and Oacoma across the Missouri River and Lake Francis Case in Brule County, South Dakota. The bridge was originally completed in 1925 and carried U.S. Route 16 (US 16) over the Missouri River. Chamberlain Bridge is designated South Dakota Department of Transportation bridge no. 08-068-084 and was listed on the National Register of Historic Places in 2001.