The Cullasaja River (/ˌkuːləˈseɪdʒə/) is a short river located entirely in Macon County, North Carolina. It is a tributary of the Little Tennessee River into which it flows near the county seat of Franklin. (The Little Tennessee feeds the Tennessee, Ohio and Mississippi rivers.) The Cullasaja originates in the southeast, near Highlands, the county's only other town. It flows from manmade Lake Sequoyah, which is fed by Mirror Lake and other creeks and streams originating on the western side of the Eastern Continental Divide, which runs through the east side of Highlands.