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Dyserythropoiesis refers to the defective development of red blood cells, also called erythrocytes. This problem can be congenital, acquired, or inherited. Some red blood cells may be destroyed within the bone marrow during the maturation process, whereas others can enter the circulation with abnormalities. These abnormalities can be functional and/or morphological, which can lead to anemia since there may be increased turnover of red blood cells. There are a number of diseases that cause dyserythropoiesis. Congenital/inherited causes include congenital dyserythropoietic anemia, thalassemia, pyruvate kinase deficiency, hereditary pyropoikilocytosis, and abetalipoproteinemia. Acquired causes include nutrient deficiency/malnutrition (e.g. cobalamine, folate, and iron), myelodysplasia, HIV in

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  • Dyserythropoiesis (en)
  • Dysérythropoïèse (fr)
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  • Dyserythropoiesis refers to the defective development of red blood cells, also called erythrocytes. This problem can be congenital, acquired, or inherited. Some red blood cells may be destroyed within the bone marrow during the maturation process, whereas others can enter the circulation with abnormalities. These abnormalities can be functional and/or morphological, which can lead to anemia since there may be increased turnover of red blood cells. There are a number of diseases that cause dyserythropoiesis. Congenital/inherited causes include congenital dyserythropoietic anemia, thalassemia, pyruvate kinase deficiency, hereditary pyropoikilocytosis, and abetalipoproteinemia. Acquired causes include nutrient deficiency/malnutrition (e.g. cobalamine, folate, and iron), myelodysplasia, HIV in (en)
  • Du grec dys- δυσ- « difficulté, anomalie », érythro- ἐρυθρός « rouge », poïèse ποίησις « action de faire », la dysérythropoïèse est une anomalie de la maturation des érythroblastes au niveau de la moelle osseuse, entraînant une insuffisance de production des érythrocytes ou globules rouges, et une anémie arégénérative. NB. Il existe une dysérythropoïse physiologique, correspondant à environ 15% de la production quotidienne d'hématie. Ils subissent une apoptose intramédullaire. Les dysérythropoïèses peuvent être : - type I: ponts interchromatiniens reliant les noyaux de certains érythroblastes; (fr)
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  • http://commons.wikimedia.org/wiki/Special:FilePath/Iron-deficiency_Anemia,_Peripheral_Blood_Smear_(4422704616).jpg
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  • A peripheral blood smear of a patient with iron-deficiency anemia, an example of an acquired dyserythropoiesis (en)
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  • Dyserythropoiesis refers to the defective development of red blood cells, also called erythrocytes. This problem can be congenital, acquired, or inherited. Some red blood cells may be destroyed within the bone marrow during the maturation process, whereas others can enter the circulation with abnormalities. These abnormalities can be functional and/or morphological, which can lead to anemia since there may be increased turnover of red blood cells. There are a number of diseases that cause dyserythropoiesis. Congenital/inherited causes include congenital dyserythropoietic anemia, thalassemia, pyruvate kinase deficiency, hereditary pyropoikilocytosis, and abetalipoproteinemia. Acquired causes include nutrient deficiency/malnutrition (e.g. cobalamine, folate, and iron), myelodysplasia, HIV infection, and certain medications (e.g. zidovudine). (en)
  • Du grec dys- δυσ- « difficulté, anomalie », érythro- ἐρυθρός « rouge », poïèse ποίησις « action de faire », la dysérythropoïèse est une anomalie de la maturation des érythroblastes au niveau de la moelle osseuse, entraînant une insuffisance de production des érythrocytes ou globules rouges, et une anémie arégénérative. NB. Il existe une dysérythropoïse physiologique, correspondant à environ 15% de la production quotidienne d'hématie. Ils subissent une apoptose intramédullaire. Les dysérythropoïèses peuvent être : * congénitales : selon le type d'anomalie, on distingue des dysérythropoïèses congénitales de type I, II ou III. * ou acquises, anémie réfractaire par exemple. Des anomalies de la maturation propres à la lignée érythroïde entraînent un "avortement médullaire". L’expression clinique se limite à une anémie et, dans certains cas, à une splénomégalie. On distingue trois types principaux de dysérythropoïèse congénitale en fonction des anomalies morphologiques des érythroblastes: - type I: ponts interchromatiniens reliant les noyaux de certains érythroblastes; - type II: érythroblastes bi ou multinucléés et lyse des érythrocytes par le sérum de certains sujets normaux liée à la présence sur la membrane de l’antigène Hempas; - type III: érythroblastes géants multinucléés. (fr)
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