About: Formyl peptide receptor

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The formyl peptide receptors (FPR) belong to a class of G protein-coupled receptors involved in chemotaxis. In humans, there are three formyl peptide receptor isoforms, each encoded by a separate gene that are named FPR1, FPR2, and FPR3. These receptors were originally identified by their ability to bind N-formyl peptides such as N-formylmethionine produced by the degradation of either bacterial or host cells. Hence formyl peptide receptors are involved in mediating immune cell response to infection. These receptors may also act to suppress the immune system under certain conditions. The close phylogenetic relation of signaling in chemotaxis and olfaction was recently proved by detection formyl peptide receptor like proteins as a distinct family of vomeronasal organ chemosensors in mice.

Attributes	Values
rdf:type	Thing Biomolecule Biomolecule Protein yago:BodyPart105220461 yago:Part109385911 yago:PhysicalEntity100001930 yago:Receptor105608868 yago:WikicatGProteinCoupledReceptors protein yago:Structure105225602 yago:Thing100002452 umbel-rc:ProteinMolecule
rdfs:label	Formyl peptide receptor (en)
rdfs:comment	The formyl peptide receptors (FPR) belong to a class of G protein-coupled receptors involved in chemotaxis. In humans, there are three formyl peptide receptor isoforms, each encoded by a separate gene that are named FPR1, FPR2, and FPR3. These receptors were originally identified by their ability to bind N-formyl peptides such as N-formylmethionine produced by the degradation of either bacterial or host cells. Hence formyl peptide receptors are involved in mediating immune cell response to infection. These receptors may also act to suppress the immune system under certain conditions. The close phylogenetic relation of signaling in chemotaxis and olfaction was recently proved by detection formyl peptide receptor like proteins as a distinct family of vomeronasal organ chemosensors in mice. (en)
foaf:name	formyl peptide receptor 1 (en) formyl peptide receptor 2 (en) formyl peptide receptor 3 (en)
name	Formyl peptide receptor 1 Formyl peptide receptor 2 Formyl peptide receptor 3
foaf:depiction
dcterms:subject	G protein-coupled receptors
Wikipage page ID	9771642 (xsd:integer)
Wikipage revision ID	1122210065 (xsd:integer)
Link from a Wikipage to another Wikipage	Endoplasmic reticulum MAPK1 MAPK1 Vomeronasal organ Hydrogen bond Cytoplasm Cytoskeleton Inflammation Amyloid Chemotaxis Ryanodine receptor N-Formylmethionine N-Formylmethionine-leucyl-phenylalanine Phosphatidylinositol (4,5)-bisphosphate Calcium channel Functional group Protein kinase C Protein structure Phospholipase C G protein G protein-coupled receptor Alpha helix Eukaryote Nicotinamide adenine dinucleotide Cell membrane Formyl peptide receptor 1 Formyl peptide receptor 2 Formyl peptide receptor 3 Transmembrane protein G protein-coupled receptors Chemokine Mitogen-activated protein kinase dbr:C-Raf CD38 FPR1 FPR2 FPR3 Inositol trisphosphate Disulfide bridge Salt bridge (protein) Extracellular signal-regulated kinases Ras (protein) Diacyl glycerol Second messenger Cyclic ADP ribose
Link from a Wikipage to an external page	http://www.iuphar-db.org/GPCR/ChapterMenuForward%3FchapterID=1359
sameAs	Formyl peptide receptor Formyl peptide receptor Formyl peptide receptor Formyl peptide receptor Formyl peptide receptor
dbp:wikiPageUsesTemplate	dbt:G_protein-coupled_receptors dbt:Cite_web dbt:Gallery dbt:MeshName dbt:Reflist dbt:Short_description dbt:Pattern_recognition_receptors dbt:Infobox_protein
thumbnail	wiki-commons:Special:FilePath/FPR.png?width=300
OMIM	136537 (xsd:integer) 136538 (xsd:integer) 136539 (xsd:integer)
AltSymbols	FPR; FMLP (en) FPRH2, FPRL2, FMLPY (en) ALXR, FMLPX, FPR2/ALX, FPR2A, FPRH1, FPRL1, HM63, LXA4R, RFP (en)
symbol	FPR1 (en) FPR2 (en) FPR3 (en)
UniProt	P21462 (en) P25089 (en) P25090 (en)
has abstract	The formyl peptide receptors (FPR) belong to a class of G protein-coupled receptors involved in chemotaxis. In humans, there are three formyl peptide receptor isoforms, each encoded by a separate gene that are named FPR1, FPR2, and FPR3. These receptors were originally identified by their ability to bind N-formyl peptides such as N-formylmethionine produced by the degradation of either bacterial or host cells. Hence formyl peptide receptors are involved in mediating immune cell response to infection. These receptors may also act to suppress the immune system under certain conditions. The close phylogenetic relation of signaling in chemotaxis and olfaction was recently proved by detection formyl peptide receptor like proteins as a distinct family of vomeronasal organ chemosensors in mice. FPR is now properly accepted as termed FPR1 by the International Union of Basic and Clinical Pharmacology. (en)
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