Frances Cox Henderson (July 21, 1820 – January 25, 1897) was the First Lady of Texas and the wife of the first Governor of Texas, James Pinckney Henderson. She was well-educated and multi-lingual, translating books in Europe. Throughout her life, she was involved in civic work such as women's suffrage, and helped run her husband's law office. She was instrumental in helping the Episcopal Church establish individual congregations in East Texas. In her final years living in New Jersey, she established the Good Shepherd home for women.