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About: GBR-13098     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:Stimulation105827684, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)

Type: Thingdul:ChemicalObjectchemical substanceChemical compoundyago:WikicatStimulantsyago:Abstraction100002137yago:Cognition100023271yago:Information105816287yago:PsychologicalFeature100023100chemical compoundyago:Stimulation105827684 New Facet based on Instances of this Class

GBR-13098 is a psychostimulant and selective dopamine uptake inhibitor. Blocking the endogenous striatal dopamine (DA) transporter with GBR-13098 in mice has been shown to prevent damage to the DA nerve terminals caused by malonate. It was suggested that DA transporter inhibitors like GBR-13098 could be used to prevent or treat neurodegenerative disorders caused by the effect of mitochondrial dysfunction on DA homeostasis.