Pike's Opera House, later renamed the Grand Opera House, was a theater in New York City on the northwest corner of 8th Avenue and 23rd Street, in the Chelsea neighborhood of Manhattan. It was constructed in 1868, at a cost of a million dollars (equivalent to about 20.4 million US dollars in 2021), for distiller and entrepreneur Samuel N. Pike (1822–1872) of Cincinnati. The building survived in altered form until 1960 as an RKO movie theater, after which it was replaced by part of Penn South, an urban renewal housing development.