About: Group II intron

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Group II introns are a large class of self-catalytic ribozymes and mobile genetic elements found within the genes of all three domains of life. Ribozyme activity (e.g., self-splicing) can occur under high-salt conditions in vitro. However, assistance from proteins is required for in vivo splicing. In contrast to group I introns, intron excision occurs in the absence of GTP and involves the formation of a lariat, with an A-residue branchpoint strongly resembling that found in lariats formed during splicing of nuclear pre-mRNA. It is hypothesized that pre-mRNA splicing (see spliceosome) may have evolved from group II introns, due to the similar catalytic mechanism as well as the structural similarity of the Group II Domain V substructure to the U6/U2 extended snRNA. Finally, their ability to

Attributes	Values
rdf:type	Thing Biomolecule Biomolecule Protein protein
rdfs:label	Group II intron (en)
rdfs:comment	Group II introns are a large class of self-catalytic ribozymes and mobile genetic elements found within the genes of all three domains of life. Ribozyme activity (e.g., self-splicing) can occur under high-salt conditions in vitro. However, assistance from proteins is required for in vivo splicing. In contrast to group I introns, intron excision occurs in the absence of GTP and involves the formation of a lariat, with an A-residue branchpoint strongly resembling that found in lariats formed during splicing of nuclear pre-mRNA. It is hypothesized that pre-mRNA splicing (see spliceosome) may have evolved from group II introns, due to the similar catalytic mechanism as well as the structural similarity of the Group II Domain V substructure to the U6/U2 extended snRNA. Finally, their ability to (en)
name	Domain X (en) Group II catalytic intron, D1-D4 (en) Group II catalytic intron, D5 (en) Group II intron, maturase-specific (en)
foaf:depiction
dct:subject	Ribozymes RNA RNA splicing
Wikipage page ID	7916185 (xsd:integer)
Wikipage revision ID	1112937161 (xsd:integer)
Link from a Wikipage to another Wikipage	Protists Pyrimidine Nucleotide Ribozymes Ribozyme In vitro In vivo Intron MRNA Open reading frame RNA splicing Fungi Gene Maturase K Small nuclear RNA Bacteria Database for bacterial group II introns Domain (biology) dbr:Adenosine Protein RNA Group I catalytic intron Guanosine triphosphate RNA splicing Biotechnology Plants Group III intron Organelle Exon Lariat (disambiguation) LtrA Twintron Spliceosome TRNA RNA Tertiary Structure RRNA Nucleophilic attack Splice site Splicing (genetics)
sameAs	Group II intron Group II intron Group II intron
dbp:wikiPageUsesTemplate	dbt:Cite_journal dbt:Refbegin dbt:Refend dbt:Reflist dbt:Short_description dbt:Infobox_rfam dbt:Pfam_box dbt:Self-replicating_organic_structures
thumbnail	wiki-commons:Special:FilePath/IntronGroupII.jpg?width=300
caption	full secondary structure of group II intron (en)
extra	180.0 (second) 300.0 (second)
InterPro	IPR013597 (en) IPR024937 (en)
Pfam	PF01348 (en) PF08388 (en)
Pfam clan	CL0359 (en)
symbol	Domain_X (en) GIIM (en) Intron_gpII (en) group-II-D1D4 (en)
has abstract	Group II introns are a large class of self-catalytic ribozymes and mobile genetic elements found within the genes of all three domains of life. Ribozyme activity (e.g., self-splicing) can occur under high-salt conditions in vitro. However, assistance from proteins is required for in vivo splicing. In contrast to group I introns, intron excision occurs in the absence of GTP and involves the formation of a lariat, with an A-residue branchpoint strongly resembling that found in lariats formed during splicing of nuclear pre-mRNA. It is hypothesized that pre-mRNA splicing (see spliceosome) may have evolved from group II introns, due to the similar catalytic mechanism as well as the structural similarity of the Group II Domain V substructure to the U6/U2 extended snRNA. Finally, their ability to site-specifically insert into DNA sites has been exploited as a tool for biotechnology. For example, group II introns can be modified to make site-specific genome insertions and deliver cargo DNA such as reporter genes or lox sites (en)
PDB	4 (xsd:integer) 6 (xsd:integer)
Rfam	RF00029 (en)
Rfam clan	CL00102 (en)
gold:hypernym	Class
prov:wasDerivedFrom	wikipedia-en:Group_II_intron?oldid=1112937161&ns=0
page length (characters) of wiki page	14774 (xsd:nonNegativeInteger)
Symbol	Domain_X GIIM
foaf:isPrimaryTopicOf	wikipedia-en:Group_II_intron
is Link from a Wikipage to another Wikipage of	Metalloprotein Retron Ribozyme Index of genetics articles Intron Prp8 Gene silencing

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