About: Histidine kinase

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Histidine kinases (HK) are multifunctional, and in non-animal kingdoms, typically transmembrane, proteins of the transferase class of enzymes that play a role in signal transduction across the cellular membrane. The vast majority of HKs are homodimers that exhibit autokinase, phosphotransfer, and phosphatase activity. HKs can act as cellular receptors for signaling molecules in a way analogous to tyrosine kinase receptors (RTK). Multifunctional receptor molecules such as HKs and RTKs typically have portions on the outside of the cell (extracellular domain) that bind to hormone- or growth factor-like molecules, portions that span the cell membrane (transmembrane domain), and portions within the cell (intracellular domain) that contain the enzymatic activity. In addition to kinase activity,

Attributes	Values
rdf:type	Thing Biomolecule Biomolecule Enzyme yago:Abstraction100002137 yago:Activator114723079 yago:Catalyst114723628 yago:Chemical114806838 yago:Compound114818238 yago:Enzyme114732946 yago:Group100031264 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 enzyme yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 yago:WikicatEnzymesOfKnownStructure yago:WikicatProteinGroups
rdfs:label	Histidinkinasen (de) Histidina quinasa (es) Histidine kinase (en)
rdfs:comment	Histidinkinasen (auch Protein-Histidinkinasen genannt) sind Enzyme, die Histidinreste in Proteinen phosphorylieren. Sie sind Teil von Signaltransduktionskaskaden, das heißt, sie registrieren Signale und lösen dann eine für dieses Signal spezifische Reaktion aus. Histidinkinasen kommen sowohl in Prokaryoten (also Archaebakterien und Eubakterien), in Pilzen als auch im Pflanzenreich vor. Nur in Tieren einschließlich des Menschen – außer in den Mitochondrien – wurden bis heute keine Histidinkinasen entdeckt. Sie weisen sehr viele Gemeinsamkeiten mit Serinkinasen auf. (de) Las histidina quinasas (HK por sus iniciales en inglés) son proteínas multifuncionales, típicamente transmembrana que actúan como transferasas de grupos fosfato. Desempeñan importantes papeles en la transducción de señales a lo largo de toda la membrana celular. La gran mayoría de las HKs son homodímeros que exhiben la propiedad de comportarse como autoquinasas, y actividad fosfatasa. Las HKs pueden actuar como receptores celulares para moléculas señalizadoras en una forma análoga a los receptores tirosina quinasas (RTK). ATP + protein L-histidina ADP + protein N-fosfo-L-histidina. (es) Histidine kinases (HK) are multifunctional, and in non-animal kingdoms, typically transmembrane, proteins of the transferase class of enzymes that play a role in signal transduction across the cellular membrane. The vast majority of HKs are homodimers that exhibit autokinase, phosphotransfer, and phosphatase activity. HKs can act as cellular receptors for signaling molecules in a way analogous to tyrosine kinase receptors (RTK). Multifunctional receptor molecules such as HKs and RTKs typically have portions on the outside of the cell (extracellular domain) that bind to hormone- or growth factor-like molecules, portions that span the cell membrane (transmembrane domain), and portions within the cell (intracellular domain) that contain the enzymatic activity. In addition to kinase activity, (en)
foaf:name	protein histidine kinase (en)
name	protein histidine kinase (en)
foaf:depiction
dcterms:subject	Enzymes of known structure EC 2.7.13
Wikipage page ID	14678550 (xsd:integer)
Wikipage revision ID	1093646355 (xsd:integer)
Link from a Wikipage to another Wikipage	Candidiasis Nucleophilic addition Nucleotide Structural motif Morphogenesis Antimicrobial Antiparallel (biochemistry) Hydrogen bond Beta sheet Response regulator Dephosphorylation Enzymology Enzymes of known structure Chemical reaction Enzyme Conformational isomerism EC 2.7.13 Substrate (biochemistry) Protein kinase dbr:Adenine Adenosine diphosphate Adenosine triphosphate Alpha helix Extracellular Kinase Dimer (chemistry) Protein domain Product (chemistry) Receptor (biochemistry) Histidine Intracellular Hydrophobe Transmembrane protein Stem-loop Homology (chemistry) Signal transduction Autocatalysis C-terminus dbr:HK1 Candida albicans Catalysis X-ray crystallography Salt bridge Thermotoga maritima Immunodeficiency Transmembrane domain N-terminus Neutrophil granulocyte Two-component regulatory system Transferase Analog (chemistry) Tyrosine kinase receptors
sameAs	Histidine kinase Histidine kinase Histidine kinase

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