About: Hook protein

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HOOK is a family of evolutionarily related proteins. This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organisms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved N-terminal domain mediates attachment to microtubules, whereas the central coiled coil motif mediates homodimerisation and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localised to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in

Attributes	Values
rdf:type	Thing Biomolecule Biomolecule Protein yago:WikicatMembraneProteins yago:Abstraction100002137 yago:Attribute100024264 yago:Chemical114806838 yago:Compound114818238 yago:Environment113934596 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 protein yago:Situation113927383 yago:Sphere114514039 yago:State100024720 yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 yago:WikicatProteinDomains
rdfs:label	Hook protein (en)
rdfs:comment	HOOK is a family of evolutionarily related proteins. This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organisms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved N-terminal domain mediates attachment to microtubules, whereas the central coiled coil motif mediates homodimerisation and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localised to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in (en)
name	HOOK protein (en)
dcterms:subject	Protein families Membrane proteins Protein domains
Wikipage page ID	31943707 (xsd:integer)
Wikipage revision ID	1082981261 (xsd:integer)
Link from a Wikipage to another Wikipage	HOOK1 HOOK2 HOOK3 Protein families Membrane proteins Protein family Protein domains Coiled coil C-terminus Organelle Microtubule N-terminus
sameAs	Hook protein Hook protein Hook protein Hook protein
dbp:wikiPageUsesTemplate	dbt:Membrane-protein-stub dbt:InterPro_content dbt:Reflist dbt:Short_description dbt:Pfam_box
InterPro	IPR008636 (en)
Pfam	PF05622 (en)
symbol	HOOK (en)
has abstract	HOOK is a family of evolutionarily related proteins. This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organisms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved N-terminal domain mediates attachment to microtubules, whereas the central coiled coil motif mediates homodimerisation and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localised to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. (en)
gold:hypernym	Family
prov:wasDerivedFrom	wikipedia-en:Hook_protein?oldid=1082981261&ns=0
page length (characters) of wiki page	2395 (xsd:nonNegativeInteger)
Symbol	HOOK
foaf:isPrimaryTopicOf	wikipedia-en:Hook_protein
is Link from a Wikipage to another Wikipage of	HOOK1 HOOK2 HOOK3
is foaf:primaryTopic of	wikipedia-en:Hook_protein

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