Hope Ruhindi Mwesigye is a Ugandan lawyer and politician. She is the former Minister for Agriculture, Animal Industry & Fisheries from 16 February 2009 until 27 May 2011. Prior to that, she served as the State Minister for Local Government, from June 2006 until February 2011. In the cabinet reshuffle of 27 May 2011, she was dropped from the cabinet and replaced by Tress Bucyanayandi.