Isaac Brown (April 13, 1942 – May 17, 2001) was an infielder/outfielder in the Negro leagues and a utilityman in Major League Baseball for the Detroit Tigers from 1969 through 1974. He batted and threw right-handed. Brown was the last former Negro league player to make it to the Major Leagues. In a six-season major league career, Brown posted a .256 batting average with 20 home runs and 65 runs batted in in 280 games played. At the time of his retirement from the Tigers in 1974, Brown was one of the last alumni of the Negro leagues (along with Hank Aaron) still active in Major League Baseball.