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Iodothyronine deiodinases (EC 1.21.99.4 and EC 1.21.99.3) are a subfamily of deiodinase enzymes important in the activation and deactivation of thyroid hormones. Thyroxine (T4), the precursor of 3,5,3'-triiodothyronine (T3) is transformed into T3 by deiodinase activity. T3, through binding a nuclear thyroid hormone receptor, influences the expression of genes in practically every vertebrate cell. Iodothyronine deiodinases are unusual in that these enzymes contain selenium, in the form of an otherwise rare amino acid selenocysteine.

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rdf:type
rdfs:label
  • Iodothyronin-Deiodinasen (de)
  • Yodotironina desyodasa (es)
  • Iodothyronine désiodase (fr)
  • Iodothyronine deiodinase (en)
rdfs:comment
  • Iodothyronin-Deiodinasen bilden eine Unterfamilie der Deiodinasen, sie spielen eine entscheidende Rolle für die Aktivierung und Inaktivierung von , Thyronaminen und . Iodothyronin-Deiodinasen sind selenabhängige Enzyme. (de)
  • Une iodothyronine désiodase est une oxydoréductase qui catalyse la désiodation d'un dérivé iodé de la thyronine, ou iodothyronine, c'est-à-dire de la thyroxine, de la triiodothyronine ou de la 3,3',5'-triiodothyronine, abrégées respectivement T4, T3 et rT3 (T3 inverse). (fr)
  • Iodothyronine deiodinases (EC 1.21.99.4 and EC 1.21.99.3) are a subfamily of deiodinase enzymes important in the activation and deactivation of thyroid hormones. Thyroxine (T4), the precursor of 3,5,3'-triiodothyronine (T3) is transformed into T3 by deiodinase activity. T3, through binding a nuclear thyroid hormone receptor, influences the expression of genes in practically every vertebrate cell. Iodothyronine deiodinases are unusual in that these enzymes contain selenium, in the form of an otherwise rare amino acid selenocysteine. (en)
  • Las yodotironina desyodasas son una subfamilia de enzimas desyodasas importantes en la activación y desactivación de las hormonas tiroideas. La tiroxina (T4), el precursor de la 3,5,3'-triyodotironina (T3) se transforma en T3 mediante la actividad deyodasa. T3, al unirse a un receptor nuclear de la hormona tiroidea, influye en la expresión de genes en prácticamente todas las células de los vertebrados. Las yodotironina desyodasas son inusuales porque estas enzimas contienen selenio, en la forma de un aminoácido selenocisteína que de otro modo sería poco común.​​​​​Estas enzimas no deben confundirse con las yodotirosina desyodasas que también son desyodasas, pero no son miembros de la familia de las yodotironinas. Las yodotirosina desyodinasas (a diferencia de las yodotironina desyodinasas) (es)
foaf:name
  • Type I thyroxine 5'-deiodinase (en)
  • Type II thyroxine 5-deiodinase (en)
  • Type III thyroxine 5-deiodinase (en)
name
  • DIO2
  • Thyroxine 5-deiodinase
  • Type I iodothyronine deiodinase (en)
  • Type I thyroxine 5'-deiodinase (en)
  • Type II thyroxine 5-deiodinase (en)
  • Type III thyroxine 5-deiodinase (en)
foaf:depiction
  • http://commons.wikimedia.org/wiki/Special:FilePath/4TR3.png
  • http://commons.wikimedia.org/wiki/Special:FilePath/Iodothyronine_deiodinase.jpg
  • http://commons.wikimedia.org/wiki/Special:FilePath/Iodothyronine_deiodinase.png
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