John C. Moore (early 1830s – October 27, 1915) was an American politician and journalist who served as the first mayor of Denver from 1859 to 1861. He was an early settler of Denver, while the area was still a territory of the United States. Moore was a newspaper journalist and publisher, working on papers in Denver, St. Louis, Kansas City, and Pueblo, Colorado. During the American Civil War, he was a judge adjutant general and colonel in the Confederate States Army.