John Walker (October 15, 1770 – May 26, 1838) was a U.S. politician from Missouri. John Walker was born in Brunswick County, Virginia. He later moved to Kentucky, and eventually settled in Howard County, Missouri in 1818. His wife Sarah Caffery, whom he married in 1800, was a niece of Rachel Jackson, the wife of Andrew Jackson. Walker was a member of a prominent Kentucky political family, and was the brother of U.S. Senator George Walker and U.S. Congressman David Walker and the uncle of James D. Walker, David S. Walker and Richard K. Call. His son John George Walker served as a Confederate general during the Civil War.