Louisiana Highway 181 (LA 181) is a state highway located in central Louisiana. It runs 4.22 miles (6.79 km) in a north–south direction from LA 115 in to U.S. Highway 71 (US 71) in Cheneyville. The route connects the small town of Cheneyville in southeastern Rapides Parish with Interstate 49 (I-49) and points along rural LA 115.