Medrie MacPhee (born 1953) is a Canadian-American painter based in New York City. She works in distinct painting and drawing series that have explored the juncture of abstraction and representation, relationships between architecture, machines, technology and human evolution, and states of flux and transformation. In the 1990s and 2000s, she gained attention for metaphorical paintings of industrial subjects and organic-machine and bio-technological forms. In later work, she explored architectural instability before turning to semiotically dense canvases combining compartments of color and collaged pieces of garments fit together like puzzles, which New York Times critic Roberta Smith described as "powerfully flat, more literal than abstract" with "an adamant, witty physicality."