The Men's United States Squash Open 2016 is the men's edition of the 2016 United States Open (squash), which is a PSA World Series event (Prize money: $150,000). The event took place at the Daskalakis Athletic Center in Philadelphia, Pennsylvania in the United States from the 8th of October to the 15th October. Mohamed El Shorbagy won his second US Open trophy, beating Nick Matthew in the final.