Minnesota State Highway 280 (MN 280) is a 3.710-mile-long (5.971 km) highway in the Twin Cities region of Minnesota that runs from its interchange with Interstate 94/US Highway 52 (I-94/US 52) in Saint Paul to its interchange with I-35W in Roseville. MN 280 is an important connector route because the junction of I-94/US 52 and I-35W in nearby downtown Minneapolis is not a complete interchange.