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NSP5 (nonstructural protein 5) encoded by genome segment 11 of group A rotaviruses. In virus-infected cells NSP5 accumulates in the viroplasms. NSP5 has been shown to be autophosphorylated.Interaction of NSP5 with NSP2 was also demonstrated. In rotavirus-infected cells, the non-structural proteins NSP5 and NSP2 localize in complexes called viroplasms, where replication and assembly occur and they can drive the formation of viroplasm-like structures in the absence of other rotaviral proteins and rotavirus replication.

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  • NSP5 (es)
  • NSP5 (rotavirus) (en)
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  • NSP5 (proteínas no estructural 5) codifica por segmento el genoma 11 del grupo A de los rotavirus. En las células infectadas por el virus NSP5 se acumula en los . El NSP5 se ha demostrado además que se autofosforila​ por la interacción de NSP5 con NSP2.​ En el rotavirus las células infectadas por las proteínas no estructurales NSP5 y NSP2 se localizan en complejos llamados , donde se producen la replicación y ensamble antes de que se pueda producir a la formación de estructuras como viroplasma en la ausencia de otras proteínas del rotavirus y la replicación misma del rotavirus.​ (es)
  • NSP5 (nonstructural protein 5) encoded by genome segment 11 of group A rotaviruses. In virus-infected cells NSP5 accumulates in the viroplasms. NSP5 has been shown to be autophosphorylated.Interaction of NSP5 with NSP2 was also demonstrated. In rotavirus-infected cells, the non-structural proteins NSP5 and NSP2 localize in complexes called viroplasms, where replication and assembly occur and they can drive the formation of viroplasm-like structures in the absence of other rotaviral proteins and rotavirus replication. (en)
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  • IPR002512 (en)
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  • PF01525 (en)
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  • Rota_NS26 (en)
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  • NSP5 (proteínas no estructural 5) codifica por segmento el genoma 11 del grupo A de los rotavirus. En las células infectadas por el virus NSP5 se acumula en los . El NSP5 se ha demostrado además que se autofosforila​ por la interacción de NSP5 con NSP2.​ En el rotavirus las células infectadas por las proteínas no estructurales NSP5 y NSP2 se localizan en complejos llamados , donde se producen la replicación y ensamble antes de que se pueda producir a la formación de estructuras como viroplasma en la ausencia de otras proteínas del rotavirus y la replicación misma del rotavirus.​ (es)
  • NSP5 (nonstructural protein 5) encoded by genome segment 11 of group A rotaviruses. In virus-infected cells NSP5 accumulates in the viroplasms. NSP5 has been shown to be autophosphorylated.Interaction of NSP5 with NSP2 was also demonstrated. In rotavirus-infected cells, the non-structural proteins NSP5 and NSP2 localize in complexes called viroplasms, where replication and assembly occur and they can drive the formation of viroplasm-like structures in the absence of other rotaviral proteins and rotavirus replication. There is no atomic-resolution structure of NSP5 determined as of June 2019. However, the low resolution three-dimensional structure of the NSP2-NSP5 assembly has been observed by cryo-EM. NSP5 occupies the same site as RNA when binding to NSP2. The EM data from this 2006 study has not been published. (en)
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  • Rota_NS26
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