The Nightingale–Brown House is a historic house at 357 Benefit Street on College Hill in Providence, Rhode Island. It is home to the John Nicholas Brown Center for Public Humanities and Cultural Heritage at Brown University. The house is architecturally significant as one of the largest surviving wood-frame houses of the 18th century, and is historically significant as the longtime seat (from 1814 to 1985) of the Brown family, whose members have been leaders of the Providence civic, social, and business community since the 17th century, and include nationally significant leaders of America's industrialization in the 19th century. The house was listed on the National Register of Historic Places and declared a National Historic Landmark in 1989.