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About: Olsalazine     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : umbel-rc:DrugProduct, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)

Type: Thingdul:ChemicalObjectchemical substanceDrugyago:WikicatAzoCompoundsyago:WikicatMolecularFormulasyago:WikicatSalicylicAcidsyago:Abstraction100002137yago:Acid114607521yago:Chemical114806838yago:Cognition100023271yago:Communication100033020yago:Compound105870180yago:Compound114818238yago:Concept105835747yago:Content105809192yago:Formula106816935yago:HydroxyAcid114613922yago:Idea105833840yago:Material114580897yago:Matter100020827yago:Message106598915yago:MolecularFormula106817173yago:Part113809207yago:PhysicalEntity100001930yago:PsychologicalFeature100023100yago:Relation100031921drugyago:SalicylicAcid115010038yago:Statement106722453yago:Substance100019613yago:Whole105869584umbel-rc:DrugProduct New Facet based on Instances of this Class

Olsalazine is an anti-inflammatory medication used in the treatment of ulcerative colitis. It is sold under the brand name Dipentum. Olsalazine itself is a pro-drug of mesalazine (5-aminosalicyclic acid or 5-ASA) and is not absorbed in the small intestine. Instead it continues through to the colon where it is cleaved into two molecules of 5-ASA by azoreductases produced by colonic bacteria. Olsalazine thus exerts its anti-inflammatory effect by its colonic breakdown into 5-ASA which inhibits cyclooxygenase and lipoxygenase thereby reducing prostaglandin and leukotriene production.