Peterboro, located approximately 25 miles (40 km) southeast of Syracuse, New York, is a historic hamlet and currently the administrative center for the Town of Smithfield, Madison County, New York, United States. Peterboro has a Post Office, ZIP code 13134. Here is the comment of a minister, visiting in 1841: This was not true elsewhere in Madison County. In the 1850 census, the population of Peterboro was 347. In 1859 there were two drug stores, a tailor's shop, two groceries, a country dry goods store, the Peterboro Academy, the Fay House (a hotel), and the closed Peterboro Hotel.