The President's Council on Bioethics (PCBE) was a group of individuals appointed by United States President George W. Bush to advise his administration on bioethics. Established on November 28, 2001, by Executive Order 13237, the council was directed to "advise the President on bioethical issues that may emerge as a consequence of advances in biomedical science and technology". It succeeded and largely replaced the National Bioethics Advisory Commission, appointed by President Bill Clinton in 1996, which expired in 2001.