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About: dbr:Proinsulin     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:WikicatPeptides, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)

Type: ThingBiomoleculeBiomoleculeProteinyago:Abstraction100002137yago:Amide114724264yago:BodySubstance105263850yago:Chemical114806838yago:Compound114818238yago:Hormone105407119yago:LiquidBodySubstance105397468yago:Macromolecule114944888yago:Material114580897yago:Matter100020827yago:Molecule114682133yago:OrganicCompound114727670yago:Part113809207yago:Peptide114743046yago:PhysicalEntity100001930yago:Protein114728724yago:Relation100031921chemical compoundproteinyago:Secretion105404728yago:Substance100019613yago:Thing100002452yago:Unit109465459yago:WikicatPeptideHormonesyago:WikicatPeptides New Facet based on Instances of this Class

Proinsulin is the prohormone precursor to insulin made in the beta cells of the islets of Langerhans, specialized regions of the pancreas. In humans, proinsulin is encoded by the INS gene. The islets of Langerhans only secrete between 1% and 3% of proinsulin intact. However, because proinsulin has a longer half life than insulin, it can account for anywhere from 5–30% of the insulin-like structures circulating in the blood. There are higher concentrations of proinsulin after meals and lower levels when a person is fasting. Additionally, while proinsulin and insulin have structural differences, proinsulin does demonstrate some affinity for the insulin receptor. Due to the relative similarities in structure, proinsulin can produce between 5% and 10% of the metabolic activity similarly induce