The Rockefeller Guest House is a building at 242 East 52nd Street in the East Midtown and Turtle Bay neighborhoods of Manhattan in New York City. Situated on the southern sidewalk of 52nd Street between Second Avenue and Third Avenue, it was designed by Philip C. Johnson and completed in 1950. The residence was constructed as a guest house for philanthropist Blanchette Rockefeller, who was married to John D. Rockefeller III. It was Johnson's only design of a private residence within New York City.