Rufus Smith Frost (July 18, 1826 – March 6, 1894) was a U.S. Representative from Massachusetts. Born in Marlborough, New Hampshire to Joseph Frost and Lucy (Wheeler) Frost, the family moved to Boston, Massachusetts, in 1833, where Frost attended the public schools. He engaged in mercantile pursuits and participated in local politics, serving as mayor of Chelsea, Massachusetts, in 1867 and 1868, as a member of the Massachusetts State Senate in 1871 and 1872, and of the Governor's council in 1873 and 1874.