SM UC-72 was a German Type UC II minelaying submarine or U-boat in the German Imperial Navy (German: Kaiserliche Marine) during World War I. The U-boat was ordered on 12 January 1916 and was launched on 12 August 1916. She was commissioned into the German Imperial Navy on 5 December 1916 as SM UC-72. In eight patrols UC-72 was credited with sinking 41 ships, either by torpedo or by mines laid. UC-72 disappeared after 21 August 1917.