About: Sandra Carson

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Sandra Ann Carson, M.D., is the principal innovator of the first artificial human ovary. This innovation was reported in the Journal of Assisted Reproduction and Genetics, and recognized by Time magazine as one of the top 10 medical breakthroughs in 2010. Clinically, the artificial ovary could play a significant role in the future, eventually yielding new infertility treatments for women by preserving the fertility of cancer patients, for example: immature eggs could be salvaged and frozen before chemotherapy or radiation, and then matured outside the patient in the artificial ovary.

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rdfs:label	Sandra Carson (en)
rdfs:comment	Sandra Ann Carson, M.D., is the principal innovator of the first artificial human ovary. This innovation was reported in the Journal of Assisted Reproduction and Genetics, and recognized by Time magazine as one of the top 10 medical breakthroughs in 2010. Clinically, the artificial ovary could play a significant role in the future, eventually yielding new infertility treatments for women by preserving the fertility of cancer patients, for example: immature eggs could be salvaged and frozen before chemotherapy or radiation, and then matured outside the patient in the artificial ovary. (en)
foaf:name	Sandra Ann Carson (en)
name	Sandra Ann Carson (en)
dcterms:subject	Living people Year of birth missing (living people) Brown University faculty Feinberg School of Medicine alumni American obstetricians
Wikipage page ID	36041768 (xsd:integer)
Wikipage revision ID	1034723142 (xsd:integer)
Link from a Wikipage to another Wikipage	Northwestern University Medical School MRNA Living people Year of birth missing (living people) Gene expression Embryos NBC Ovary Parents (magazine) 20/20 (U.S. TV program) Brown University faculty Brown University CBS CNN Time (magazine) Granulosa cells American Broadcasting Company American Congress of Obstetricians and Gynecologists Feinberg School of Medicine alumni Chemotherapy American obstetricians Time Magazine Theca cells Infertility Women & Infants Hospital of Rhode Island Mademoiselle (magazine) Warren Alpert Medical School US Food and Drug Administration Polar bodies
sameAs	Sandra Carson Sandra Carson Sandra Carson Sandra Carson
dbp:wikiPageUsesTemplate	dbt:Authority_control dbt:Infobox_person dbt:Reflist
education	Residency: Northwestern Memorial Hospital (en) Medical School: Northwestern University Medical School (en) Fellowship: Michael Reese Hospital and Medical Center (en)
known for	Inventing the first artificial human ovary (en)
occupation	Doctor and researcher (en)
has abstract	Sandra Ann Carson, M.D., is the principal innovator of the first artificial human ovary. This innovation was reported in the Journal of Assisted Reproduction and Genetics, and recognized by Time magazine as one of the top 10 medical breakthroughs in 2010. In this work, Carson, et al. introduced theca cells donated by reproductive-age patients into "3-D Petri dishes" designed to resemble the sponge-like cells of a human ovary. In the lab, the cell types interacted with one another and functioned for all intents and purposes like a real ovary, even successfully maturing a human egg from its earliest stages in the follicle to a fully developed form. To build the ovary, honeycombs of theca cells were formed, one of two key types in the ovary, donated by reproductive-age patients at Women & Infants Hospital of Rhode Island. Together with human egg cells, donated granulosa cells were inserted into the honeycomb shape the theca cells formed. In days, the theca cells enveloped the granulosa and eggs, mimicking a real ovary. Clinically, the artificial ovary could play a significant role in the future, eventually yielding new infertility treatments for women by preserving the fertility of cancer patients, for example: immature eggs could be salvaged and frozen before chemotherapy or radiation, and then matured outside the patient in the artificial ovary. In parallel with this effort and a scientific first, Carson co-directed a research team by extracting information about gene expression from fertile human egg cells without hurting them. In this work the team was able to sequence the transcribed genetic material, or mRNA, in egg cells, in smaller structures pinched off from them called polar bodies. Polar bodies are nonfunctional and incapable of being fertilized. This new technique could ultimately give parents and doctors a preview of which eggs are likely to make the most viable embryos. (en)
gold:hypernym	Innovator
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foaf:isPrimaryTopicOf	wikipedia-en:Sandra_Carson
is Link from a Wikipage to another Wikipage of	Alpert Medical School Feinberg School of Medicine Carson (surname) Sandra carson
is Wikipage redirect of	Sandra carson
is foaf:primaryTopic of	wikipedia-en:Sandra_Carson

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