Santo Manzanillo (born December 20, 1988) is a Dominican former professional baseball player. Manzanillo grew up in Santo Domingo. He worked on his uncle's farm, where they grew sugar cane. When he was 16 years old, scouts for the Milwaukee Brewers approached him about trying out. Manzanillo initially declined, but was convinced to try out by his family. The scouts helped tutor Manzanillo in pitching, and after he pitched in an exhibition game, the Brewers offered Manzanillo a contract.