Sayama Domain (狭山藩, Sayama-han) was a feudal domain under the Tokugawa shogunate of Edo period Japan, located in Kawachi Province in what is now the southeastern portion of modern-day Osaka Prefecture. It was centered around the Sayama jin'ya which was located in what is now the city of Ōsakasayama and was controlled by the tozama daimyō Hōjō clan throughout all of its history.