Sean Estrada (born May 23, 1985) is a former American football guard and center who played for the San Francisco 49ers of the National Football League. He was originally signed by the 49ers as an undrafted free agent in 2007. He played college football at Pennsylvania. He attended Servite High School and graduated in 2003. While at the University of Pennsylvania Sean lettered in football for 3 years. He was a two time All-Ivy League guard who was elected Unanimous First-team All-Ivy League his senior year. He also served as team captain for the Quakers in the 2006 season.