Sir William Bowyer, 1st Baronet (29 June 1612 – 2 October 1679), was an English politician who sat in the House of Commons between 1659 and 1679. Bowyer was the eldest son of Sir Henry Bowyer and his wife Anne Salter, daughter of Sir Nicholas Salter, and was baptised at St Olave's Church, Hart Street, London. On 29 May 1634, he married Margaret Weld, daughter of Sir John Weld at St Olave's Church, Old Jewry, London. They had three sons and several daughters. Bowyer died intestate, aged 67, and was buried at Denham. He was succeeded in the baronetcy by his oldest son William.