The Great Hotel Murder is a 1935 American mystery film directed by Eugene Forde and starring Edmund Lowe, Victor McLaglen, Rosemary Ames and Mary Carlisle. It is based on Recipe for Murder a 1934 story by Vincent Starrett. The film stars Lowe and McLaglen as rival sleuths, with supporting roles for Lynn Bari and Madge Bellamy. It was one of a series of films featuring Lowe and McLaglen as friendly rivals dating back to their first pairing in the hit 1926 silent film What Price Glory?.