U.S. Route 278 (US 278) in the U.S. state of Georgia is an east–west United States Highway traversing the north-central portion of the state. The highway travels from the Alabama state line near Esom Hill to the South Carolina state line where it crosses the Savannah River in the Augusta metropolitan area. It is also concurrent with I-20 from exit 75 in Lithonia until it reaches exit 90 in Covington in Newton County. US 278 largely travels parallel to I-20 from DeKalb County, near Atlanta, to McDuffie County.