U.S. Route 341 (US 341) is a 224-mile-long (360 km) U.S. highway entirely in the U.S. state of Georgia. It travels diagonally across southern Georgia (but is signed as north–south) from Brunswick at US 17/SR 25 to Barnesville at US 41/SR 7/SR 18. It is a spur route of US 41 and has two intersections with it: in Perry and at its northern terminus in Barnesville.