U.S. Highway 6 (US 6) in the U.S. state of Nebraska is a highway which goes from the Colorado border west of Imperial in the west to the Iowa border in the east at Omaha. Significant portions of the highway are concurrent with other highways, most significantly, U.S. Highway 34 between Culbertson and Hastings. Also, from Milford east to the Iowa border, the highway is closely paralleled by Interstate 80. Large portions of the route parallel the Chicago, Burlington and Quincy Railroad.