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About: UNC (biology)     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:WikicatReceptors, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)

Type: yago:BodyPart105220461yago:Part109385911yago:PhysicalEntity100001930yago:Receptor105608868yago:Structure105225602yago:Thing100002452yago:WikicatReceptors New Facet based on Instances of this Class

UNC is a set of proteins first identified through a set of screening tests in Caenorhabditis elegans, looking for roundworms with movement problems. Worms with which were un-coordinated (hence UNC) were analysed in order to identify the genetic defect. Such proteins include UNC-5, a receptor for UNC-6 which is one of the netrins. Netrins are a class of proteins involved in axon guidance. UNC-5 uses repulsion (genetics) to direct axons while the other netrin receptor UNC-40 attracts axons to the source of netrin production.