Van Zylsrus is a settlement in John Taolo Gaetsewe District Municipality in the Northern Cape province of South Africa. It is also the nearest settlement to The Kalahari Meerkat Project, the filming of nature TV shows such as Meerkat Manor. The settlement was founded by 6 Trekboer families in 1832, led by the former Heemrad of Calvinia, Petrus van Zyl.