USS Newcomb (DD-586) was a Fletcher-class destroyer in the United States Navy during World War II. She was the only ship named for Commodore Frank H. Newcomb of the United States Revenue Cutter Service, Congressional Gold Medal recipient from the Spanish–American War. Newcomb was laid down on 19 March 1943 by Boston Navy Yard and launched on 4 July 1943, sponsored by Mrs. C. C. Baughman. The ship was commissioned on 10 November 1943.