The 1922 City of London by-election was a parliamentary by-election held on 19 May 1922 for the British House of Commons constituency of City of London, which covered the "Square Mile" which was the United Kingdom's traditional financial district. The seat had become vacant on the elevation to the peerage of one of the constituency's two Unionist Members of Parliament (MPs), Arthur James Balfour, as the Earl of Balfour.