The 1945 Clemson Tigers football team was an American football team that represented Clemson College during the 1945 college football season. In its sixth season under head coach Frank Howard, the team compiled a 6–3–1 record (2–1–1 against conference opponents), finished fourth in the conference, and outscored opponents by a total of 211 to 73. The team played its home games at Memorial Stadium in Clemson, South Carolina. Tackle Bob Turner and center Ralph Jenkins were selected as first-team players on the 1945 All-Southern Conference football team.