The 1945 Oklahoma Sooners football team represented the University of Oklahoma in the 1945 college football season. In their fifth year under head coach Dewey Luster, the Sooners compiled a 5–5 record (4–1 against conference opponents), finished in second place in the Big Six Conference championship, and outscored their opponents by a combined total of 169 to 138. No Sooners received All-America honors in 1945, but five Sooners received all-conference honors: Omer Burgert (end); Lester Jensen (guard); Thomas Tallchief (tackle); Jack Venable (back); and John West (back).