The 1959 Colorado Buffaloes football team was an American football team that represented the University of Colorado in the Big Seven Conference during the 1959 NCAA University Division football season. Led by first-year head coach Sonny Grandelius, the Buffaloes compiled an overall record of 5–5 with a mark of 3–3 in conference play, tying for third place in the Big 7. The team played its home games on campus at Folsom Field in Boulder, Colorado.