The 1959 North Texas State Eagles football team represented the University of North Texas as a member of the Missouri Valley Conference (MVC) during the 1959 NCAA University Division football season. The Eagles, coached by Odus Mitchell, compiled a 9–2 record, and outscored their opponents 303 to 103. The Eagles were ranked for two weeks in the AP Poll. They shared the MVC title with Houston and finished the season with a 28–8 loss to New Mexico State in the 1959 Sun Bowl.