The 1980–81 Liga Bet season saw Hapoel Migdal HaEmek, Beitar Haifa, Hapoel Azor and Hapoel Yeruham win their regional divisions and promoted to Liga Alef. At the bottom, , (from North A division), Hapoel Kiryat Yam, (from North B division), Maccabi Ramla, (from South A division), Maccabi Shikun HaMizrah and Beitar Ashdod (from South B division) were all automatically relegated to Liga Gimel.